Abstract
Reactive oxygen species (ROS), especially hydroxyl radicals are postulated to mediate apoptosis of the cell. Here we demonstrate that hydroxyl radicals generated selectively by photolysis of a photo-Fenton reagent, N,N'-bis(2-hydroperoxy-2-methoxyethyl)-1,4,5,8-naphthaldiimide (NP-III), induce apoptosis in HL-60 (human promyelocytic leukemia) cells involving the activation of caspase-3.
MeSH terms
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Apoptosis / drug effects*
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Caspase 3
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Caspases / analysis
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Caspases / metabolism
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HL-60 Cells / drug effects*
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Humans
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Hydroxyl Radical / pharmacology*
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Hydroxyl Radical / radiation effects
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Naphthalenes
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Photochemistry
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Radiation-Sensitizing Agents
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Reactive Oxygen Species / pharmacology
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Reactive Oxygen Species / radiation effects
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Ultraviolet Rays
Substances
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Naphthalenes
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Radiation-Sensitizing Agents
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Reactive Oxygen Species
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N,N'-bis(2-hydroxyperoxy-2-methoxyethyl)-1,4,5,8-naphthalenetetracarboxylic diimide
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Hydroxyl Radical
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CASP3 protein, human
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Caspase 3
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Caspases