Total synthesis of the mycolactones

Fengbin Song; Steve Fidanze; Andrew B Benowitz; Yoshito Kishi

doi:10.1021/ol0172828

Total synthesis of the mycolactones

Org Lett. 2002 Feb 21;4(4):647-50. doi: 10.1021/ol0172828.

Authors

Fengbin Song¹, Steve Fidanze, Andrew B Benowitz, Yoshito Kishi

Affiliation

¹ Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

PMID: 11843613
DOI: 10.1021/ol0172828

Abstract

[structure: see text] The first total synthesis of the mycolactones is reported. This work unambiguously confirms our earlier relative and absolute stereochemical assignment of the mycolactones.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Indicators and Reagents
Lactones / chemical synthesis*
Lactones / chemistry
Macrolides
Magnetic Resonance Spectroscopy
Molecular Conformation
Mycobacterium ulcerans / chemistry*

Substances

Indicators and Reagents
Lactones
Macrolides
mycolactone A
mycolactone B

Grants and funding

CA 22215/CA/NCI NIH HHS/United States