Abstract
The synthesis of 2-(2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-thiazolidin-4-one (3) from p,p'-dichlorochalcone (1) via 1,3,3-tris(4-chlorophenyl)-propan-1-one (2) using thioglycollic acid in the presence of ammonium carbonate is described. Structural assignment, stereochemistry and biological assay are discussed.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / pharmacology*
-
Chalcone / analogs & derivatives
-
Chalcone / chemistry*
-
Chalcones
-
Chlorobenzenes / chemical synthesis*
-
Chlorobenzenes / pharmacology*
-
Cross-Linking Reagents
-
Dose-Response Relationship, Drug
-
Drug Screening Assays, Antitumor
-
Humans
-
Inhibitory Concentration 50
-
Thiazoles / chemical synthesis*
-
Thiazoles / pharmacology*
-
Thiazolidines
-
Tumor Cells, Cultured
Substances
-
2-(2,2-bis(4-chlorophenyl)ethyl)-2-(4-chlorophenyl)thiazolidin-4-one
-
4,4'-dichlorochalcone
-
Antineoplastic Agents
-
Chalcones
-
Chlorobenzenes
-
Cross-Linking Reagents
-
Thiazoles
-
Thiazolidines
-
Chalcone