Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism

Chirality. 2002 Feb-Mar;14(2-3):215-9. doi: 10.1002/chir.10058.

Abstract

We present the results of a study using vibrational circular dichroism (VCD) for (+)-1, which furnished an unambiguous determination of its absolute configuration as S. The most abundant conformation of (+)-1 in CDCl(3) solution was also established.

MeSH terms

  • Antidiuretic Hormone Receptor Antagonists*
  • Benzodiazepines / chemistry*
  • Circular Dichroism
  • Molecular Conformation
  • Solvents
  • Spectrophotometry, Infrared

Substances

  • Antidiuretic Hormone Receptor Antagonists
  • Solvents
  • Benzodiazepines