Abstract
Synaptic signaling, memory formation, neuronal development, and neuronal pathology are strongly influenced by the properties of intracellular Ca2+ channels, ryanodine, and inositol 1, 4, 5 trisphosphate receptors. This review will focus on recently developed and discovered pharmacological tools to modulate these channel proteins at the single-channel level. It will allow the readers of Molecular Neurobiology to evaluate the current knowledge on the pharmacological modulation of intracellular Ca2+ channels and to direct future research efforts effectively using available experimental tools and concepts.
MeSH terms
-
Animals
-
Calcium Channels / drug effects
-
Calcium Channels / physiology*
-
Ethanol / pharmacology
-
Inositol 1,4,5-Trisphosphate Receptors
-
Intracellular Fluid / physiology
-
Neurons / physiology
-
Polyamines / pharmacology
-
Receptors, Cytoplasmic and Nuclear / drug effects
-
Receptors, Cytoplasmic and Nuclear / physiology
-
Ruthenium Red / pharmacology
-
Ryanodine Receptor Calcium Release Channel / drug effects
-
Ryanodine Receptor Calcium Release Channel / physiology
-
Signal Transduction
-
Sulfhydryl Reagents / pharmacology
-
Synapses / physiology*
Substances
-
Calcium Channels
-
Inositol 1,4,5-Trisphosphate Receptors
-
Polyamines
-
Receptors, Cytoplasmic and Nuclear
-
Ryanodine Receptor Calcium Release Channel
-
Sulfhydryl Reagents
-
Ruthenium Red
-
Ethanol