Abstract
The title compound, C(12)H(12)N(2)O(3)S, is a strict pyridine analogue of nimesulide, a selective inhibitor of cyclooxygenase-2. The structure is characterized by a pyridinium ring with a deprotonated sulfonamide group. An intermolecular charge-assisted hydrogen bond between these two groups is observed within the crystal packing, linking the molecules into an infinite chain running along the b-axis direction.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminopyridines / chemistry*
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Crystallography, X-Ray
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / chemistry*
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Hydrogen Bonding
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Isoenzymes / antagonists & inhibitors*
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Models, Molecular
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Prostaglandin-Endoperoxide Synthases
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Sulfonamides / chemistry*
Substances
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Aminopyridines
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Isoenzymes
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N-(3-phenoxy-4-pyridinio)methanesulfonamidate
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Sulfonamides
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases
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nimesulide