Abstract
The investigation involved 30 patients with locally advanced breast cancer (T3-4N1-2M0). Combination therapy comprised two courses: carboplatin 300 mg/m2, i.v., dropwise, on day 1; doxorubicin 30 mg/m2, i.v., bolus-flow, on days 1 and 8; 5-fluorouracil 350 mg/m2, i.v., bolus-flow, on days 1 and 8, and irradiation of the breast and regional metastasis area (single target dose--2 Gy, total target dose--40 Gy). Overall clinical response was 96.7% (29/30), mammography-wise--83.3% (25/30). All patients were found operable and radical mastectomy was performed in 25. Therapeutic effect stage III-IV was histologically confirmed in 40% (25/30), stage I-II--60% (15/25). Median overall and recurrence-free survival was not reached within 36 months in 24/30, relapse-free survival was been reported in 16/24 (66.6%), tumor progression--8/24 (33.4%). Three-year; host-mastectomy recurrence-free survival--68.8 +/- 16.0%.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adult
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Antibiotics, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic / administration & dosage
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Antineoplastic Agents / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Breast Neoplasms / drug therapy
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Breast Neoplasms / mortality
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Breast Neoplasms / radiotherapy
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Breast Neoplasms / surgery
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Breast Neoplasms / therapy*
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Carboplatin / administration & dosage
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Carcinoma, Ductal, Breast / drug therapy
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Carcinoma, Ductal, Breast / mortality
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Carcinoma, Ductal, Breast / radiotherapy
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Carcinoma, Ductal, Breast / surgery
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Carcinoma, Ductal, Breast / therapy*
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Carcinoma, Lobular / drug therapy
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Carcinoma, Lobular / mortality
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Carcinoma, Lobular / radiotherapy
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Carcinoma, Lobular / surgery
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Carcinoma, Lobular / therapy*
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Combined Modality Therapy
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Doxorubicin / administration & dosage
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Female
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Fluorouracil / administration & dosage
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Humans
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Mammography
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Mastectomy, Radical
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Middle Aged
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Radiotherapy Dosage
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Survival Analysis
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Time Factors
Substances
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Antibiotics, Antineoplastic
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Antimetabolites, Antineoplastic
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Antineoplastic Agents
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Doxorubicin
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Carboplatin
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Fluorouracil