Objective: To investigate drug concentration in tumor tissues after intraperitoneal chemotherapy with carboplatin.
Method: High performance liquid chromatography was used to study the pharmacokinetics of carboplatin in 10 patients with resectable advanced gastric cancer after intraperitoneal chemotherapy. 300 mg/m(2) carboplatin in 750 ml 0.9% sodium chloride were intraperitoneally injected. After 160 - 180 minutes, peritoneal fluid, blood of portal vein and peripheric blood were collected. 240 - 270 minutes later, cancer tissues, normal tissues, peritoneum, omentum, and normal lymph nodes were taken. The total carboplatin concentrations were measured.
Result: Drug concentration was highest in the peritoneal fluid, followed by that the in blood of portal vein. They were 8 times, 1.6 times of the concentration in peripheric blood. The concentration in the peritoneum was higher than in other tissues (P < 0.05). The concentration in tumor tissues was higher than that in normal tissues.
Conclusion: Intraperitoneal chemotherapy with carboplatin chemotherapy increased its concentration in the peritoneal cavity and the blood of portal vein, and its accumulation in the peritoneum and tumor tissues, which help eliminate subclinical lesions, improve clinical stage, control iatrogenic metastasis, and increase resectable rate.