Objective: To report the familial occurrence of severe oligoasthenoteratozoospermia in a man and five male relatives related through their mothers.
Design: Case report.
Setting: University medical center.
Patient(s): Six affected family members.
Main outcome measure(s): Blood and semen samples were collected from all affected males and some of their healthy male relatives. Pedigree analysis and exclusion of X-linked disorder were done.
Result(s): Analysis suggested that familial nonsyndromic male factor infertility was present.
Conclusion(s): The family described in this report suggests the existence of an autosomal dominant trait of male infertility with sex-limited expression.