Antitumor agents. Part 212. Bucidarasins A-C, three new cytotoxic clerodane diterpenes from Bucida buceras

Bioorg Med Chem Lett. 2002 Feb 11;12(3):345-8. doi: 10.1016/s0960-894x(01)00742-9.

Abstract

As part of a study on antitumor agents from rainforest plants, four new clerodane diterpenes, bucidarasins A--D (1-4), were isolated from Bucida buceras. Their structures were elucidated from detailed 2D NMR analyses. Compounds 1-3 showed potent cytotoxicity against human tumor cell lines with IC(50) values of 0.5-1.9 microM. The potency was retained in drug resistant lines.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Chromatography, High Pressure Liquid
  • Diterpenes / chemical synthesis*
  • Diterpenes / chemistry*
  • Diterpenes / pharmacology*
  • Diterpenes, Clerodane*
  • Drug Resistance, Neoplasm
  • Drug Screening Assays, Antitumor
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Plant Extracts / chemistry
  • Plants, Medicinal / chemistry*
  • Spectrophotometry, Infrared
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Diterpenes, Clerodane
  • Plant Extracts
  • bucidarasin A
  • bucidarasin B
  • bucidarasin C