Dendroaspis natriuretic peptide-like immunoreactivity and its regulation in rat aortic vascular smooth muscle

Peptides. 2002 Jan;23(1):23-9. doi: 10.1016/s0196-9781(01)00575-7.

Abstract

Dendroaspis natriuretic peptide (DNP) is a recently isolated 38 amino acid peptide that shares structural and functional properties with the other members of the natriuretic peptide family. The present study demonstrates the presence of DNP-like immunoreactivity in sections of rat aorta, carotid artery and renal vasculature and tubules. DNP-like immunoreactivity was detected in culture aortic vascular smooth muscle cells and medium and is regulated by endothelin-1, angiotensin II and sodium nitroprusside but not by transforming growth factor-beta. Our observations indicate that DNP elicits a marked inhibitory effect on DNA synthesis in culture rat aortic vascular smooth muscle cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Angiotensin II / biosynthesis
  • Animals
  • Aorta / metabolism*
  • Carotid Arteries / metabolism
  • Cell Division
  • Cells, Cultured
  • DNA / biosynthesis
  • Elapid Venoms / chemistry*
  • Elapid Venoms / metabolism
  • Elapidae / metabolism*
  • Endothelin-1 / biosynthesis
  • Endothelium, Vascular / metabolism*
  • Immunohistochemistry
  • Intercellular Signaling Peptides and Proteins
  • Kidney / blood supply
  • Kidney Tubules / metabolism
  • Male
  • Microscopy, Fluorescence
  • Molecular Sequence Data
  • Muscle, Smooth / metabolism*
  • Nitroprusside / pharmacology
  • Peptides / chemistry*
  • Peptides / metabolism
  • Protein Binding
  • Radioimmunoassay
  • Rats
  • Rats, Wistar
  • Time Factors
  • Transforming Growth Factor beta / pharmacology

Substances

  • Dendroaspis natriuretic peptide
  • Elapid Venoms
  • Endothelin-1
  • Intercellular Signaling Peptides and Proteins
  • Peptides
  • Transforming Growth Factor beta
  • Angiotensin II
  • Nitroprusside
  • DNA