Abstract
Dendroaspis natriuretic peptide (DNP) is a recently isolated 38 amino acid peptide that shares structural and functional properties with the other members of the natriuretic peptide family. The present study demonstrates the presence of DNP-like immunoreactivity in sections of rat aorta, carotid artery and renal vasculature and tubules. DNP-like immunoreactivity was detected in culture aortic vascular smooth muscle cells and medium and is regulated by endothelin-1, angiotensin II and sodium nitroprusside but not by transforming growth factor-beta. Our observations indicate that DNP elicits a marked inhibitory effect on DNA synthesis in culture rat aortic vascular smooth muscle cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Angiotensin II / biosynthesis
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Animals
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Aorta / metabolism*
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Carotid Arteries / metabolism
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Cell Division
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Cells, Cultured
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DNA / biosynthesis
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Elapid Venoms / chemistry*
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Elapid Venoms / metabolism
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Elapidae / metabolism*
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Endothelin-1 / biosynthesis
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Endothelium, Vascular / metabolism*
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Immunohistochemistry
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Intercellular Signaling Peptides and Proteins
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Kidney / blood supply
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Kidney Tubules / metabolism
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Male
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Microscopy, Fluorescence
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Molecular Sequence Data
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Muscle, Smooth / metabolism*
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Nitroprusside / pharmacology
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Peptides / chemistry*
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Peptides / metabolism
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Protein Binding
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Radioimmunoassay
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Rats
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Rats, Wistar
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Time Factors
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Transforming Growth Factor beta / pharmacology
Substances
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Dendroaspis natriuretic peptide
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Elapid Venoms
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Endothelin-1
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Intercellular Signaling Peptides and Proteins
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Peptides
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Transforming Growth Factor beta
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Angiotensin II
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Nitroprusside
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DNA