The telencephalo-habenulo-interpeduncular connections have been studied in the brain of the cartilaginous fish Chiloscyllium arabicum. In addition to telencephalic and diencephalic projections to the habenula and to habenulo-interpeduncular projection, the presence of a direct telencephalo-interpeduncular connection confirmed some homologies of this system in cartilaginous fishes with actinopterigian fishes and land vertebrates.