Abstract
Hepatitis B virus (HBV) is spread worldwide. Seven genotypes, A-G, have been described, differing by more than 8% of the genome. In eastern Asia and Oceania genotypes B and C are predominant. However, little is known about genotypes in Mongolia and Australian aborigines. We analysed the preS and S regions of HBV from 9 Mongols and 5 Australian Aborigines. All Mongolian strains were of genotype D and were most similar to Central Asian sequences. All the Australian strains were genetically of serotype ayw3, and could not be reliably classified by the S region analysis, but placed on a separate branch. By preS analysis, they were however clearly of genotype C. The 6-7% nucleotide difference from published Asian genotype C sequences suggests that they diverged from Asian genotype C branch more than 1000 years ago.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Asian People*
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Australia / epidemiology
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Genotype
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Hepatitis B / ethnology*
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Hepatitis B / virology
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Hepatitis B Surface Antigens / genetics
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Hepatitis B virus / classification*
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Hepatitis B virus / genetics*
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Humans
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Molecular Sequence Data
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Mongolia / epidemiology
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Native Hawaiian or Other Pacific Islander*
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Phylogeny
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Polymorphism, Restriction Fragment Length
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Sequence Analysis, DNA
Substances
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Hepatitis B Surface Antigens
Associated data
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GENBANK/AF360954
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GENBANK/AF360955
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GENBANK/AF360956
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GENBANK/AF360957
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GENBANK/AF360958
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GENBANK/AF360959
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GENBANK/AF360960
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GENBANK/AF360961
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GENBANK/AF360962
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GENBANK/AF360963
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GENBANK/AF360964
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GENBANK/AF360965
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GENBANK/AF360966
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GENBANK/AF360967
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GENBANK/AF360968
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GENBANK/AF360969
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GENBANK/AF360970
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GENBANK/AF360971
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GENBANK/AF360972
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GENBANK/AF360973
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GENBANK/AF360974
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GENBANK/AF360975
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GENBANK/AF360976
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GENBANK/AF360977
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GENBANK/AF360978