[The role of chemotherapy in the treatment of non-metastatic, non-small cell bronchial cancers]

J P Sculier; T Berghmans; M Paesmans; F Branle; F Lemaitre; C Mascaux; A P Meert; E Steels; F Vallot; J J Lafitte

[The role of chemotherapy in the treatment of non-metastatic, non-small cell bronchial cancers]

Rev Med Brux. 2001 Dec;22(6):477-87.

[Article in French]

Authors

J P Sculier¹, T Berghmans, M Paesmans, F Branle, F Lemaitre, C Mascaux, A P Meert, E Steels, F Vallot, J J Lafitte

Affiliation

¹ Département de Médecine Interne et Laboratoire d'Investigation Clinique H.J. Tagnon, Institut Jules Bordet, Centre des Tumeurs de l'U.L.B. Lille.

PMID: 11811043

Abstract

A systematic review of the literature about the role of chemotherapy in comparison to local therapies--surgery or radiotherapy--in non-small cells lung cancers has identified 35 randomised trials. The methodological assessment has not shown significant difference for quality scores between negative or positive studies in term of survival effect. The aggregation (meta-analysis) shows a significant effect of survival improvement by chemotherapy, whatever all indications are considered or subgroups like adjuvant chemotherapy to surgery, neoadjuvant chemotherapy, concomitant radio-chemotherapy and induction chemotherapy prior to thoracic irradiation.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Belgium / epidemiology
Carcinoma, Bronchogenic / drug therapy*
Carcinoma, Bronchogenic / epidemiology
Carcinoma, Bronchogenic / pathology
Carcinoma, Non-Small-Cell Lung / drug therapy*
Carcinoma, Non-Small-Cell Lung / epidemiology
Carcinoma, Non-Small-Cell Lung / pathology
Combined Modality Therapy
Humans
Lung Neoplasms / drug therapy*
Lung Neoplasms / epidemiology
Lung Neoplasms / pathology
Neoadjuvant Therapy / methods
Neoadjuvant Therapy / standards
Neoplasm Staging
Pneumonectomy / standards
Radiotherapy, Adjuvant / standards
Research Design / standards
Survival Analysis
Treatment Outcome