Objective: To observe the clinical therapeutic effect of Lixin Pill (LXP) in treating patients with congestive heart failure (CHF).
Methods: Ninety CHF patients with heart function of III-IV grade were randomly divided into 3 groups. Group A was treated with LXP, Group B with LXP plus small dosage of digoxin and Group C with ordinary dosage of digoxin. The therapeutic course for all the three groups was 1 month. Meanwhile, all patients were given ordinary dosage of diuretics, nitrates and angiotensin-converting enzyme inhibitors (ACEI) as basic therapy.
Results: The total effective rate in improving heart function in Group A, B and C was 83.3%, 93.3% and 90.0% respectively. In respect of improving myocardial contraction and dilation, the left ventricular ejection fraction (LVEF) was improved in all the three groups but was more superior in Group B (P < 0.05); the ratio of maximum blood flow between the advanced and the early diastolic stage (A/E) was improved, and the complicated supraventricular and ventricular premature contraction in Group A and B were reduced markedly after treatment (P < 0.01 or P < 0.05), and the effect in Group B was superior to that in Group A.
Conclusion: Using LXP combined with small dosage of digoxin could improve the therapeutic effect in treating patients suffering from congestive heart failure.