Objective: To study the therapeutic effect, side effects and cognize improvement of Risperidone in treating different TCM Syndrome-types of first-episode schizophrenia.
Methods: Applying Risperidone to treat first-episode schizophrenics who were divided into Phlegm-Dampness type, Phlegm-Fire type and other types in TCM, and observing them with PANSS, TESS and Wisconsin Card Sorting Test (WCST).
Results: It is important to assess the therapeutic effect of patient with Fire Syndrome or without. Insomnia is the most prevalent side effect, while akathisia in Phlegm-Fire type is the most serious side effect, cognition deficiency in Phlegm-Dampness type is the most serious before treatment, and reduction of total card number of WCST in Phlegm-Fire type is significant after treatment (P < 0.05).
Conclusion: It is the best way to use Risperidone combined with TCM Syndrome Differentiation so as to elevate the efficacy.