[Prevalence of viral hepatitis G infection in hemodialysis patients and coinfection with viral hepatitis B and C]

Vnitr Lek. 2001 Oct;47(10):678-81.
[Article in Czech]

Abstract

The group of infectious agents causing viral hepatitis was extended by another virus the detection of which was published in 1995. This virus is described as virus of hepatitis G (HGV) or GBV-C virus and is included among RNA viruses family Flaviviridae. Detection of HGV is based on reverse transcription with subsequent amplification of the viral nucleic acid by means of a polymerase chain reaction. The authors examined sera of 82 chronically haemodialyzed patients incl. 22 (26.8%) HGV RNA positive ones, whereby coinfection with HBV was proved in 3 specimens (13%). In 6 HGV RNA positive samples anti-HCV positivity was found (27%), incl. one sample where HCV RNA positivity was proved (4.5%). Raised transaminase activity was found only in three patients with HGV RNA positivity (13.6%). From the presented results ensues that haemodialyzed patients are a high risk group for HGV infection.

Publication types

  • English Abstract

MeSH terms

  • Flaviviridae Infections / complications
  • Flaviviridae Infections / diagnosis
  • Flaviviridae Infections / epidemiology*
  • GB virus C* / isolation & purification
  • Hepatitis B / complications*
  • Hepatitis B / diagnosis
  • Hepatitis B / epidemiology
  • Hepatitis C / complications*
  • Hepatitis C / diagnosis
  • Hepatitis C / epidemiology
  • Hepatitis, Viral, Human / epidemiology*
  • Hepatitis, Viral, Human / etiology
  • Humans
  • RNA, Viral / blood
  • Renal Dialysis / adverse effects*
  • Risk Factors
  • Seroepidemiologic Studies

Substances

  • RNA, Viral