Abstract
We have developed a computational subtraction approach to detect microbial causes for putative infectious diseases by filtering a set of human tissue-derived sequences against the human genome. We demonstrate the potential of this method by identifying sequences from known pathogens in established expressed-sequence tag libraries.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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DNA, Viral / genetics
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DNA, Viral / isolation & purification
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Databases, Genetic
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Expressed Sequence Tags
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Gene Library
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Genetics, Microbial*
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Genome, Human*
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Genome, Viral
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Humans
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Sequence Analysis, DNA
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Viruses / genetics
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Viruses / pathogenicity