Hybridization between "six-membered" nucleic acids: RNA as a universal information system

L Kerremans; G Schepers; J Rozenski; R Busson; A Van Aerschot; P Herdewijn

doi:10.1021/ol016183r

Hybridization between "six-membered" nucleic acids: RNA as a universal information system

Org Lett. 2001 Dec 27;3(26):4129-32. doi: 10.1021/ol016183r.

Authors

L Kerremans¹, G Schepers, J Rozenski, R Busson, A Van Aerschot, P Herdewijn

Affiliation

¹ Katholieke Universiteit Leuven, Rega Institute, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

PMID: 11784159
DOI: 10.1021/ol016183r

Abstract

Within the polyA:polyT recognition system, cross-pairing between several nucleic acids with a phosphorylated six-membered carbohydrate (mimic) as repeating unit in the backbone structure has been observed. All investigated nucleic acids (except for beta-homo-DNA) hybridize with RNA, leaving RNA as a versatile biopolymer for informational transfer. [reaction: see text]

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Nucleic Acid Conformation
RNA / chemistry*

Substances

RNA