Thiopurine methyl transferase: activity and genotyping in patients with acute lymphoblastic leukemia

Adv Exp Med Biol. 2000:486:327-31. doi: 10.1007/0-306-46843-3_63.

Authors

C Brouwer¹, J J Keizer-Garritsen, L H Lambooy, K Ament, P G Ter Riet, R A De Abreu, J P Bökkerink, E R Van Wering, A Van Der Does-Van Den Berg, A J Veerman, J P Trijbels

Affiliation

¹ Center for Pediatric Oncology S.E. Netherlands, University Medical Center St Radboud, Department of Pediatrics, Nijmegen.

PMID: 11783509
DOI: 10.1007/0-306-46843-3_63

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Antimetabolites, Antineoplastic / therapeutic use
Child
Female
Genetic Testing
Genotype
Humans
Male
Mercaptopurine / therapeutic use
Methotrexate / therapeutic use
Methyltransferases / genetics*
Methyltransferases / metabolism*
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics

Substances

Antimetabolites, Antineoplastic
Mercaptopurine
Methyltransferases
thiopurine methyltransferase
Methotrexate