Objective: To assess the role of CA125 monoclonal antibody in the differential diagnosis of primary ovarian carcinoma and metastatic ovarian carcinoma originated from the gastrointestinal tract.
Methods: Immunohistochemical study using CA125 monoclonal antibody was performed on 33 primary ovarian cancer and 50 metastatic ovarian cancer of gastrointestinal origin.
Results: The positivity of CA125 was 84.5% in 33 cases of primary ovarian carcinoma, while in 50 metastatic ovarian carcinoma cases, only 4.0% was CA125 positive. The positivity of CA125 was significantly higher in primary ovarian carcinoma than metastatic ovarian carcinoma (P < 0.001).
Conclusion: CA125 monoclonal antibody is useful in the differential diagnosis of ovarian carcinoma.