Objective: To explore the effect of ovariectomy caused Kidney Deficiency on the metabolism of bone in mice with collagen induced arthritis.
Methods: The mice for experiment were immunized with subcutaneous injection of type II collagen to induce arthritis after ovariectomy. Severity of joint swelling, radioimmunoassay of serum estradiol (E2), osteocalcin (OC) and tumor necrosis factor (TNF), and pathological changes of joint, including changes on synovia, articular cartilage and bone, were observed once weekly.
Results: The E2 level of ovariectomized mice dropped down obviously, while the contents of OC and TNF increased significantly. Severe pathological changes can be seen in synovial tissues, cartilage and bone.
Conclusion: Kidney Deficiency caused by ovariectomy exacerbated the pathological changes of collagen-induced arthritis in mice.