Regulating sister chromatid separation by separase phosphorylation

Koji Nagao; Mitsuhiro Yanagida

doi:10.1016/s1534-5807(01)00112-5

Regulating sister chromatid separation by separase phosphorylation

Dev Cell. 2002 Jan;2(1):2-4. doi: 10.1016/s1534-5807(01)00112-5.

Authors

Koji Nagao¹, Mitsuhiro Yanagida

Affiliation

¹ Department of Biophysics, Graduate School of Science, Kyoto University, 606-8502 Kyoto, Japan.

PMID: 11782307
DOI: 10.1016/s1534-5807(01)00112-5

Abstract

A recent paper in Cell highlights a second mechanism of regulation of separase in addition to the bound inhibitor securin. This second pathway involves separase phosphorylation and is dependent on CDC2.

Publication types

Review

MeSH terms

Animals
Cell Cycle Proteins / metabolism*
Chromatids / metabolism*
Endopeptidases*
Phosphorylation
S Phase / physiology
Separase

Substances

Cell Cycle Proteins
Endopeptidases
Separase