Abstract
We report increased numbers of hematogones in a 7-year-old girl with pancytopenia due to Shwachman-Diamond syndrome. Her hematogones expressed the T-cell marker CD5 as well as CD19, CD10, and CD20, and terminal deoxynucleotidyl transferase and HLA-DR. These findings suggest that hematogones are precursors of both CD5-positive B cells and CD5-negative B cells. Thus CD5-positive B cells in bone marrow may be derived from bone marrow stem cells, and not from the residual fetal B cells of yolk sac/liver origin. The finding of CD5 expression on hematogones also raises the possibility that neoplastic B cells of chronic lymphocytic leukemia, which characteristically co-express CD5 and CD19, may be derived from CD5-positive B-cell precursors in bone marrow and not from mature B cells in lymph nodes.
MeSH terms
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B-Lymphocytes / metabolism
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B-Lymphocytes / pathology*
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Bone Marrow Cells / metabolism
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Bone Marrow Cells / pathology
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CD5 Antigens / biosynthesis*
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Child
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DNA Nucleotidylexotransferase / biosynthesis
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Exocrine Pancreatic Insufficiency / diagnostic imaging
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Exocrine Pancreatic Insufficiency / metabolism
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Exocrine Pancreatic Insufficiency / pathology*
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Female
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Flow Cytometry
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Growth Disorders
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HLA-DR Antigens / biosynthesis
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Hematopoietic Stem Cells / metabolism
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Hematopoietic Stem Cells / pathology*
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Humans
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Immunoenzyme Techniques
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Immunophenotyping
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In Situ Hybridization, Fluorescence
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Leukemia, Lymphocytic, Chronic, B-Cell / etiology
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Leukemia, Lymphocytic, Chronic, B-Cell / metabolism
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology
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Pancreas / diagnostic imaging
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Pancreas / pathology
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Syndrome
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Tomography, X-Ray Computed
Substances
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CD5 Antigens
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HLA-DR Antigens
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DNA Nucleotidylexotransferase