Hybridization properties of aromatic peptide nucleic acids: a novel class of oligonucleotide analogues

Lee D Fader; Youla S Tsantrizos

doi:10.1021/ol010231q

Hybridization properties of aromatic peptide nucleic acids: a novel class of oligonucleotide analogues

Org Lett. 2002 Jan 10;4(1):63-6. doi: 10.1021/ol010231q.

Authors

Lee D Fader¹, Youla S Tsantrizos

Affiliation

¹ Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6.

PMID: 11772091
DOI: 10.1021/ol010231q

Abstract

[structure: see text] The synthesis of APNA-PNA chimeras containing all four DNA bases will be described. The hybridization properties of APNA-PNA chimeras with DNA and RNA are consistent with plausible intramolecular interactions that could preorganize the oligomers in a duplex or triplex structure with complementary DNA or RNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / chemistry
Nucleic Acid Hybridization
Oligonucleotides / chemistry*
Peptide Nucleic Acids / chemistry*
RNA / chemistry

Substances

Oligonucleotides
Peptide Nucleic Acids
RNA
DNA