Abstract
We have developed a route for the synthesis of 2'-selenium uridine analogues and oligonucleotides containing selenium labels, and have demonstrated for the first time a new strategy to covalently derivatize nucleotides with selenium for phase and structure determination in X-ray crystallography.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Crystallography, X-Ray
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DNA / chemistry
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Oligonucleotides / chemistry*
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Organoselenium Compounds / chemical synthesis
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Organoselenium Compounds / chemistry*
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RNA / chemistry
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Spectrometry, Fluorescence
Substances
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Oligonucleotides
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Organoselenium Compounds
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RNA
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DNA