Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative

Bioorg Med Chem Lett. 2002 Jan 21;12(2):265-6. doi: 10.1016/s0960-894x(01)00728-4.

Abstract

The bis(S-pivaloyl-2-thioethyl) phosphotriester derivative of 9-(4'-hydroxy-1',2'-butadienyl)adenine (adenallene) was synthesized. This mononucleotide prodrug proved to be more effective than the parent nucleoside in inhibiting HIV-1 replication in several human T4 lymphoblastoid cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / chemistry
  • Adenine / pharmacology*
  • Cell Line
  • Esters
  • HIV-1 / drug effects*
  • HIV-1 / physiology
  • Humans
  • Reverse Transcriptase Inhibitors / chemistry
  • Reverse Transcriptase Inhibitors / pharmacology*
  • Virus Replication / drug effects

Substances

  • Esters
  • Reverse Transcriptase Inhibitors
  • adenallene
  • Adenine