Abstract
Four new alkaloids (1-4) were isolated from the marine sponge Axinella brevistyla, and their structures were determined on the basis of spectroscopic analysis. The alkaloids 1-4 were antifungal against the yeast Saccharomyces cerevisiae at <1.0, <1.0, 30, and 100 microg/disk, respectively. Compounds 1-3 also exhibited cytotoxicity against L1210 cells with IC(50) values of 1.1, 0.66, and 2.5 microg/mL, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Chromatography, High Pressure Liquid
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Drug Screening Assays, Antitumor
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Inhibitory Concentration 50
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Japan
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Leukemia L1210
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Mass Spectrometry
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / chemistry*
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Pyrroles / chemistry
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Pyrroles / isolation & purification*
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Pyrroles / pharmacology
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Saccharomyces cerevisiae / drug effects
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Stereoisomerism
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Structure-Activity Relationship
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Tumor Cells, Cultured / drug effects
Substances
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Alkaloids
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Antifungal Agents
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Antineoplastic Agents
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Pyrroles