Comparative studies of the biological activities of lysosomotropic aminoesters and quaternary ammonium salts on the yeast Saccharomyces cerevisiae

E Obłak; T M Lachowicz; J Luczyński; S Witek

Comparative studies of the biological activities of lysosomotropic aminoesters and quaternary ammonium salts on the yeast Saccharomyces cerevisiae

Cell Mol Biol Lett. 2001;6(4):871-80.

Authors

E Obłak¹, T M Lachowicz, J Luczyński, S Witek

Affiliation

¹ Institute of Microbiology, University of Wrocław, Przybyszewskiego 65/73, 51-148 Wrocław, Poland.

PMID: 11753434

Abstract

The biological activity of lysosomotropic n-alkyl N,N-dimethylglycinates (DMG-n) was compared with that of a quaternary ammonium salt IM (methochloride of DMG-12). The activity of the glycinates appeared to be carbon chain length dependent and was similar at pH 6 and pH 8. Nutritional auxotrophy and respiratory deficiencies have no influence on DMG-n sensitivity. Both IM and DMG-n inhibit plasma membrane H+-ATPase activity while mitochondrial ATPase is relatively non-sensitive to glycinates. No cross-resistance to IM and DMG-n was observed.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphatases / metabolism
Hydrogen-Ion Concentration
Lysosomes / drug effects*
Mitochondria / enzymology
Proton-Translocating ATPases / metabolism
Quaternary Ammonium Compounds / pharmacology*
Saccharomyces cerevisiae / drug effects*
Saccharomyces cerevisiae / metabolism

Substances

Quaternary Ammonium Compounds
Adenosine Triphosphatases
Proton-Translocating ATPases