Crystal structure of [Cu(N-quinolin-8-yl-p-toluenesulfonamidate)(2)]: study of its interaction with DNA and hydrogen peroxide

J Inorg Biochem. 2002 Jan 1;88(1):101-7. doi: 10.1016/s0162-0134(01)00302-6.

Abstract

A new copper complex with N-quinolin-8-yl-p-toulenesulfonamide has been prepared and characterised. The compound crystallises in the triclinic system, space group P1, with a=13.457(3), b=15.067(5), c=18.589(3) A; alpha=112.05(2), beta=93.92(2), gamma=108.30(2) degrees and Z=4. The geometry of the Cu(II) ion is distorted square planar. The N-quinolin-8-yl-p-toulenesulfonamidate anion behaves as a bidentate ligand through the N(sulfonamidate)and N(quinoline) atoms. The complex does not cleave DNA in the presence of hydrogen peroxide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Copper / chemistry*
  • Copper / pharmacology
  • Crystallography, X-Ray
  • DNA / chemistry*
  • DNA Damage
  • Dose-Response Relationship, Drug
  • Hydrogen Peroxide / chemistry*
  • Hydrolysis / drug effects
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / metabolism
  • Organometallic Compounds / pharmacology
  • Plasmids
  • Quinolines / chemistry*
  • Quinolines / pharmacology
  • Spectrum Analysis
  • Sulfonamides / chemistry*
  • Sulfonamides / metabolism
  • Sulfonamides / pharmacology

Substances

  • Cu(N-quinolin-8-yl-p-toluenesulfonamidate)(2)
  • Organometallic Compounds
  • Quinolines
  • Sulfonamides
  • Copper
  • DNA
  • Hydrogen Peroxide