Abstract
A new copper complex with N-quinolin-8-yl-p-toulenesulfonamide has been prepared and characterised. The compound crystallises in the triclinic system, space group P1, with a=13.457(3), b=15.067(5), c=18.589(3) A; alpha=112.05(2), beta=93.92(2), gamma=108.30(2) degrees and Z=4. The geometry of the Cu(II) ion is distorted square planar. The N-quinolin-8-yl-p-toulenesulfonamidate anion behaves as a bidentate ligand through the N(sulfonamidate)and N(quinoline) atoms. The complex does not cleave DNA in the presence of hydrogen peroxide.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Copper / chemistry*
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Copper / pharmacology
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Crystallography, X-Ray
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DNA / chemistry*
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DNA Damage
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Dose-Response Relationship, Drug
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Hydrogen Peroxide / chemistry*
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Hydrolysis / drug effects
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Molecular Structure
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Organometallic Compounds / chemistry*
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Organometallic Compounds / metabolism
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Organometallic Compounds / pharmacology
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Plasmids
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Quinolines / chemistry*
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Quinolines / pharmacology
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Spectrum Analysis
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Sulfonamides / chemistry*
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Sulfonamides / metabolism
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Sulfonamides / pharmacology
Substances
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Cu(N-quinolin-8-yl-p-toluenesulfonamidate)(2)
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Organometallic Compounds
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Quinolines
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Sulfonamides
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Copper
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DNA
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Hydrogen Peroxide