Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice

Br J Cancer. 2001 Dec 14;85(12):1964-7. doi: 10.1054/bjoc.2001.2188.

Abstract

One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Animals
  • Antibiotics, Antineoplastic / immunology*
  • Antibiotics, Antineoplastic / toxicity
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal / immunology
  • Antibodies, Monoclonal / therapeutic use*
  • Antibody Specificity
  • Apoptosis / drug effects*
  • Doxorubicin / immunology*
  • Doxorubicin / toxicity
  • Drug Evaluation, Preclinical
  • Female
  • Glossitis / chemically induced
  • Glossitis / pathology
  • Glossitis / prevention & control
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Mouth Mucosa / drug effects
  • Mouth Mucosa / pathology
  • Stomatitis / chemically induced
  • Stomatitis / pathology
  • Stomatitis / prevention & control*
  • Tongue / drug effects
  • Tongue / pathology

Substances

  • Antibiotics, Antineoplastic
  • Antibodies, Monoclonal
  • Doxorubicin