Abstract
5-Demethylovalicin was isolated from the fermentation broth Chrysosporium lucknowense and the structure was identified by spectroscopic methods. 5-Demethylovalicin inhibited the recombinant human MetAP-2 (IC(50)=17.7 nM) and the growth of human umbilical vein endothelial cells (HUVEC; IC(50)=100 nM) in cell proliferation assay without cytotoxicity on the transformed and cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminopeptidases / antagonists & inhibitors*
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Cells, Cultured
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Chrysosporium / metabolism*
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Enzyme Inhibitors / pharmacology*
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Humans
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Metalloendopeptidases / antagonists & inhibitors*
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Recombinant Proteins / antagonists & inhibitors
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Sesquiterpenes / pharmacology*
Substances
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5-demethylovalicin
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Enzyme Inhibitors
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Recombinant Proteins
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Sesquiterpenes
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Aminopeptidases
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methionine aminopeptidase 2
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Metalloendopeptidases