5-demethylovalicin, as a methionine aminopeptidase-2 inhibitor produced by Chrysosporium

Bioorg Med Chem. 2002 Jan;10(1):185-8. doi: 10.1016/s0968-0896(01)00268-1.

Abstract

5-Demethylovalicin was isolated from the fermentation broth Chrysosporium lucknowense and the structure was identified by spectroscopic methods. 5-Demethylovalicin inhibited the recombinant human MetAP-2 (IC(50)=17.7 nM) and the growth of human umbilical vein endothelial cells (HUVEC; IC(50)=100 nM) in cell proliferation assay without cytotoxicity on the transformed and cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminopeptidases / antagonists & inhibitors*
  • Cells, Cultured
  • Chrysosporium / metabolism*
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Metalloendopeptidases / antagonists & inhibitors*
  • Recombinant Proteins / antagonists & inhibitors
  • Sesquiterpenes / pharmacology*

Substances

  • 5-demethylovalicin
  • Enzyme Inhibitors
  • Recombinant Proteins
  • Sesquiterpenes
  • Aminopeptidases
  • methionine aminopeptidase 2
  • Metalloendopeptidases