A bioactive spirolactone iridoid and triterpenoids from Himatanthus sucuuba

Chem Pharm Bull (Tokyo). 2001 Nov;49(11):1477-8. doi: 10.1248/cpb.49.1477.

Abstract

Himatanthus sucuuba is an Amazonian tree with abundant, yet conflicting ethnobotanical information. Investigation of the polar and non-polar constituents led to the isolation of plumericin, a bioactive spirolactone iridoid, and four known pentacylic triterpenes: lupeol acetate, lupeol cinnamate, lupeol beta-phenyl propionate, and alpha-amyrin cinnamate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3T3 Cells
  • Animals
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Apocynaceae / chemistry*
  • HT29 Cells
  • Humans
  • Indenes / chemistry*
  • Indenes / isolation & purification
  • Indenes / pharmacology
  • Iridoids
  • Mice
  • Mice, Inbred BALB C
  • Plant Bark / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / metabolism
  • Plant Extracts / pharmacology
  • Spironolactone / chemistry*
  • Spironolactone / isolation & purification
  • Spironolactone / pharmacology
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology
  • Tumor Cells, Cultured

Substances

  • Antifungal Agents
  • Antineoplastic Agents, Phytogenic
  • Indenes
  • Iridoids
  • Plant Extracts
  • Triterpenes
  • Spironolactone
  • plumericin