Abstract
Himatanthus sucuuba is an Amazonian tree with abundant, yet conflicting ethnobotanical information. Investigation of the polar and non-polar constituents led to the isolation of plumericin, a bioactive spirolactone iridoid, and four known pentacylic triterpenes: lupeol acetate, lupeol cinnamate, lupeol beta-phenyl propionate, and alpha-amyrin cinnamate.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3T3 Cells
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Apocynaceae / chemistry*
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HT29 Cells
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Humans
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Indenes / chemistry*
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Indenes / isolation & purification
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Indenes / pharmacology
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Iridoids
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Mice
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Mice, Inbred BALB C
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / metabolism
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Plant Extracts / pharmacology
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Spironolactone / chemistry*
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Spironolactone / isolation & purification
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Spironolactone / pharmacology
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
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Tumor Cells, Cultured
Substances
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Antifungal Agents
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Antineoplastic Agents, Phytogenic
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Indenes
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Iridoids
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Plant Extracts
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Triterpenes
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Spironolactone
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plumericin