Cacofurans A and B, new furanoditerpenes from a marine sponge

J Nat Prod. 2001 Nov;64(11):1468-70. doi: 10.1021/np010203g.

Abstract

Two new labdane-class diterpenes, cacofurans A (1) and B (2), have been isolated from a sponge Cacospongia sp. Their structures were determined by analyzing spectroscopic data, by chemical transformations, and by X-ray diffraction. Cacofurans 1 and 2 inhibited the development of fertilized sea urchin eggs at concentrations of 0.5 and 5 microg/mL and showed an actin-disrupting effect on the NBT-II cell line at 10 microg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid
  • Convolvulaceae / chemistry*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Dose-Response Relationship, Drug
  • Furans / chemistry
  • Furans / isolation & purification*
  • Furans / pharmacology
  • Japan
  • Leukemia, Lymphoid
  • Male
  • Mice
  • Molecular Conformation
  • Molecular Structure
  • Porifera / chemistry*
  • Rats
  • Sea Urchins / drug effects
  • Sea Urchins / embryology
  • Spermatozoa / drug effects
  • Stereoisomerism
  • Tumor Cells, Cultured / drug effects
  • Urinary Bladder Neoplasms
  • X-Ray Diffraction

Substances

  • Diterpenes
  • Furans
  • cacofuran A
  • cacofuran B