Abstract
ETS-domain transcription-factor networks represent a model for how combinatorial gene expression is achieved. These transcription factors interact with a multitude of co-regulatory partners to elicit gene-specific responses and drive distinct biological processes. These proteins are controlled by a complex series of inter and intramolecular interactions, and signalling pathways impinge on these proteins to further regulate their action.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
DNA / metabolism
-
Humans
-
Models, Biological
-
Models, Molecular
-
Multigene Family
-
Neoplasms / metabolism
-
Phosphorylation
-
Protein Binding
-
Protein Structure, Tertiary
-
Proto-Oncogene Proteins / physiology*
-
Proto-Oncogene Proteins c-ets
-
Transcription Factors / physiology*
Substances
-
Proto-Oncogene Proteins
-
Proto-Oncogene Proteins c-ets
-
Transcription Factors
-
DNA