Stereoselective synthesis of 7 alpha- and 7 beta-aminocholestanol as potent fungicidal drugs

S Fouace; L El kihel; M Dherbomez; Y Letourneux

doi:10.1016/s0960-894x(01)00609-6

Stereoselective synthesis of 7 alpha- and 7 beta-aminocholestanol as potent fungicidal drugs

Bioorg Med Chem Lett. 2001 Dec 3;11(23):3011-4. doi: 10.1016/s0960-894x(01)00609-6.

Authors

S Fouace¹, L El kihel, M Dherbomez, Y Letourneux

Affiliation

¹ Laboratoire de Synthèse et Etude de Substances Naturelles à Activités Biologiques, Université de La Rochelle, Pôle Sciences et Technologies, 17042 La Rochelle, France.

PMID: 11714599
DOI: 10.1016/s0960-894x(01)00609-6

Abstract

Potentially lymphotropic 7 alpha- and 7 beta-aminocholestanol were stereoselectively synthesized. In vitro bioassay studies have shown that these fungicidal lipidic derivatives possess strong antifungal activity against Candida spp resistant strains to amphotericin B, 5-fluorocytosine and azoles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amphotericin B / pharmacology
Antifungal Agents / chemical synthesis
Antifungal Agents / chemistry*
Antifungal Agents / pharmacology*
Biochemistry / methods
Candida / drug effects
Cholestanols / chemical synthesis
Cholestanols / pharmacology
Drug Evaluation, Preclinical
Flucytosine / pharmacology
Microbial Sensitivity Tests
Stereoisomerism

Substances

Antifungal Agents
Cholestanols
Amphotericin B
Flucytosine