Abstract
A new approach to the chemical control of respiratory syncytial virus infection is reviewed in the context of the biology of the virus and previous treatment approaches. Conjugation of the interferon action mediator, 2',5'-oligoadenylate (2-5A), to antisense agents provides a strategy for the selective ablation of RNA. This application of this technology to respiratory syncytial virus has provided a potent selective inhibitor of virus replication.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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2',5'-Oligoadenylate Synthetase / genetics
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2',5'-Oligoadenylate Synthetase / metabolism
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Adenine Nucleotides / chemistry
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Adenine Nucleotides / pharmacology*
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Adenosine Triphosphate / metabolism
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Antisense Elements (Genetics) / chemistry
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Antisense Elements (Genetics) / pharmacology*
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Antiviral Agents / pharmacology*
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Child
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Child, Preschool
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Computer Simulation
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Drug Design
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Endoribonucleases / metabolism
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Enzyme Induction
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Humans
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Infant
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Interferons / physiology*
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Models, Molecular
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Oligoribonucleotides / chemistry
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Oligoribonucleotides / pharmacology*
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RNA, Double-Stranded / antagonists & inhibitors*
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RNA, Double-Stranded / genetics
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RNA, Double-Stranded / metabolism
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RNA, Viral / antagonists & inhibitors*
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RNA, Viral / genetics
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RNA, Viral / metabolism
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Respiratory Syncytial Virus Infections / drug therapy*
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Respiratory Syncytial Viruses / drug effects*
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Respiratory Syncytial Viruses / genetics
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Respiratory Syncytial Viruses / physiology
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Substrate Specificity
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Virus Replication / drug effects
Substances
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Adenine Nucleotides
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Antisense Elements (Genetics)
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Antiviral Agents
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Oligoribonucleotides
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RNA, Double-Stranded
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RNA, Viral
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2',5'-oligoadenylate
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Adenosine Triphosphate
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Interferons
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2',5'-Oligoadenylate Synthetase
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Endoribonucleases
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2-5A-dependent ribonuclease