Chemical modification of chitosan: preparation and lectin binding properties of alpha-galactosyl-chitosan conjugates. Potential inhibitors in acute rejection following xenotransplantation

H Sashiwa; J M Thompson; S K Das; Y Shigemasa; S Tripathy; R Roy

doi:10.1021/bm005536r

Chemical modification of chitosan: preparation and lectin binding properties of alpha-galactosyl-chitosan conjugates. Potential inhibitors in acute rejection following xenotransplantation

Biomacromolecules. 2000 Fall;1(3):303-5. doi: 10.1021/bm005536r.

Authors

H Sashiwa¹, J M Thompson, S K Das, Y Shigemasa, S Tripathy, R Roy

Affiliation

¹ Department of Chemistry, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5.

PMID: 11710115
DOI: 10.1021/bm005536r

Abstract

Water-soluble alpha-galactosyl-chitosan conjugates were prepared by reductive amination of p-formylphenyl beta-melibioside on chitosan in good yield. Strong binding with phytohemagglutinin was demonstrated using Griffonia simplicifolia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrate Sequence
Chitin / analogs & derivatives
Chitin / chemistry*
Chitosan
Galactose / analogs & derivatives*
Galactose / chemistry*
Graft Rejection / prevention & control*
Immunosuppressive Agents / chemical synthesis*
Immunosuppressive Agents / pharmacology
Lectins / chemistry*
Molecular Sequence Data
Plant Lectins*
Transplantation, Heterologous / immunology

Substances

Griffonia simplicifolia lectins
Immunosuppressive Agents
Lectins
Plant Lectins
Chitin
Chitosan
Galactose