Abstract
The in vitro activity of a novel oxazolidinone, linezolid, was studied by comparing the activity of linezolid with those of amikacin, trimethoprim-sulfamethoxazole, and amoxicillin-clavulanic acid against 25 strains of Nocardia brasiliensis isolated from patients with mycetoma. All N. brasiliensis strains tested were sensitive to linezolid (MIC at which 90% of strains are inhibited [MIC(90)], 2 microg/ml; MIC(50), 1 microg/ml). This antimicrobial might constitute a good alternative for treatment of actinomycetoma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / pharmacology*
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Amikacin / pharmacology
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Amoxicillin-Potassium Clavulanate Combination / pharmacology
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Anti-Bacterial Agents / pharmacology*
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Dermatomycoses / microbiology*
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Drug Therapy, Combination / pharmacology
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Humans
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Linezolid
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Microbial Sensitivity Tests
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Nocardia / drug effects*
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Nocardia Infections / microbiology*
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Oxazolidinones / pharmacology*
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Trimethoprim, Sulfamethoxazole Drug Combination / pharmacology
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Amoxicillin-Potassium Clavulanate Combination
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Trimethoprim, Sulfamethoxazole Drug Combination
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Amikacin
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Linezolid