In vitro activity of PNU-100766 (linezolid), a new oxazolidinone antimicrobial, against Nocardia brasiliensis

Antimicrob Agents Chemother. 2001 Dec;45(12):3629-30. doi: 10.1128/AAC.45.12.3629-3630.2001.

Abstract

The in vitro activity of a novel oxazolidinone, linezolid, was studied by comparing the activity of linezolid with those of amikacin, trimethoprim-sulfamethoxazole, and amoxicillin-clavulanic acid against 25 strains of Nocardia brasiliensis isolated from patients with mycetoma. All N. brasiliensis strains tested were sensitive to linezolid (MIC at which 90% of strains are inhibited [MIC(90)], 2 microg/ml; MIC(50), 1 microg/ml). This antimicrobial might constitute a good alternative for treatment of actinomycetoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / pharmacology*
  • Amikacin / pharmacology
  • Amoxicillin-Potassium Clavulanate Combination / pharmacology
  • Anti-Bacterial Agents / pharmacology*
  • Dermatomycoses / microbiology*
  • Drug Therapy, Combination / pharmacology
  • Humans
  • Linezolid
  • Microbial Sensitivity Tests
  • Nocardia / drug effects*
  • Nocardia Infections / microbiology*
  • Oxazolidinones / pharmacology*
  • Trimethoprim, Sulfamethoxazole Drug Combination / pharmacology

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Amoxicillin-Potassium Clavulanate Combination
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Amikacin
  • Linezolid