In silico screening for tumour-specific expressed sequences in human genome

FEBS Lett. 2001 Nov 9;508(1):143-8. doi: 10.1016/s0014-5793(01)03028-9.

Abstract

A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.

MeSH terms

  • Databases, Genetic
  • Expressed Sequence Tags
  • Gene Expression Profiling / methods*
  • Gene Library
  • Genes, Neoplasm*
  • Genome, Human*
  • Humans
  • Neoplasms / genetics*