Abstract
Most current models of spindle assembly checkpoint signaling involve inhibition of the Cdc20-APC by Mad2 protein. Interestingly, a paper from Hongtao Yu and colleagues in this issue of Developmental Cell suggests that the Cdc20/APC can also be inhibited in a Mad2-independent manner by a complex of proteins that includes BubR1.
MeSH terms
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Animals
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Calcium-Binding Proteins / metabolism*
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Carrier Proteins*
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Cdc20 Proteins
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Cell Cycle Proteins / metabolism*
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Cell Cycle*
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Fungal Proteins / metabolism*
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Humans
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Kinetochores / physiology*
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Mad2 Proteins
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Models, Biological
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Nuclear Proteins
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Protein Binding
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Protein Kinases / metabolism*
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Protein Serine-Threonine Kinases
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Saccharomyces cerevisiae / physiology
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Saccharomyces cerevisiae Proteins*
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Signal Transduction
Substances
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CDC20 protein, S cerevisiae
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Calcium-Binding Proteins
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Carrier Proteins
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Cdc20 Proteins
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Cell Cycle Proteins
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Fungal Proteins
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MAD2 protein, S cerevisiae
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Mad2 Proteins
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Nuclear Proteins
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Saccharomyces cerevisiae Proteins
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Protein Kinases
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BUB1 protein, human
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Bub1 spindle checkpoint protein
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Protein Serine-Threonine Kinases