Tracing the pathway of spindle assembly checkpoint signaling

Dev Cell. 2001 Aug;1(2):162-4. doi: 10.1016/s1534-5807(01)00032-6.

Abstract

Most current models of spindle assembly checkpoint signaling involve inhibition of the Cdc20-APC by Mad2 protein. Interestingly, a paper from Hongtao Yu and colleagues in this issue of Developmental Cell suggests that the Cdc20/APC can also be inhibited in a Mad2-independent manner by a complex of proteins that includes BubR1.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Calcium-Binding Proteins / metabolism*
  • Carrier Proteins*
  • Cdc20 Proteins
  • Cell Cycle Proteins / metabolism*
  • Cell Cycle*
  • Fungal Proteins / metabolism*
  • Humans
  • Kinetochores / physiology*
  • Mad2 Proteins
  • Models, Biological
  • Nuclear Proteins
  • Protein Binding
  • Protein Kinases / metabolism*
  • Protein Serine-Threonine Kinases
  • Saccharomyces cerevisiae / physiology
  • Saccharomyces cerevisiae Proteins*
  • Signal Transduction

Substances

  • CDC20 protein, S cerevisiae
  • Calcium-Binding Proteins
  • Carrier Proteins
  • Cdc20 Proteins
  • Cell Cycle Proteins
  • Fungal Proteins
  • MAD2 protein, S cerevisiae
  • Mad2 Proteins
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins
  • Protein Kinases
  • BUB1 protein, human
  • Bub1 spindle checkpoint protein
  • Protein Serine-Threonine Kinases