Cocaine withdrawal in Planaria

Eur J Pharmacol. 2001 Oct 26;430(1):143-5. doi: 10.1016/s0014-2999(01)01358-9.

Abstract

Cocaine-exposed planarians displayed abstinence-induced withdrawal behavior when placed into cocaine-free, but not cocaine-containing, water. The effect, manifested and quantified using a new spontaneous locomotor velocity metric, was dose-dependently related to cocaine exposure (8x10(-9) to 8x10(-5) M). Ultraviolet light (254 nm=7.83x10(-19) J), which was previously shown to interfere with drug-receptor interactions in Planaria, enhanced the abstinence-induced decreased locomotor velocity.

MeSH terms

  • Animals
  • Cocaine / toxicity*
  • Disease Models, Animal
  • Locomotion / drug effects
  • Planarians / drug effects*
  • Planarians / radiation effects
  • Temperature
  • Ultraviolet Rays

Substances

  • Cocaine