Fulminant hepatic failure secondary to adenovirus following fludarabine-based chemotherapy for non-Hodgkin's lymphoma

Leuk Lymphoma. 2001 Sep-Oct;42(5):1145-50. doi: 10.3109/10428190109097738.

Abstract

Self-limited adenoviral infections are very common with the majority of infections resolving rapidly. Fatal complications may occur in severely immunocompromised patients. We describe a case of fulminant hepatic failure due to adenovirus in a 54-year-old man treated with fludarabine and cyclophosphamide for non-Hodgkin's lymphoma. There are no previous reports of this complication in conjunction with purine nucleoside therapy.

Publication types

  • Case Reports

MeSH terms

  • Adenoviridae Infections / chemically induced*
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Autopsy
  • Fatal Outcome
  • Humans
  • Liver Failure / etiology*
  • Liver Failure / pathology
  • Liver Failure / virology
  • Lymphoma, Non-Hodgkin / complications*
  • Lymphoma, Non-Hodgkin / drug therapy
  • Male
  • Middle Aged
  • Vidarabine / administration & dosage
  • Vidarabine / analogs & derivatives*
  • Vidarabine / toxicity*

Substances

  • Vidarabine
  • fludarabine