Abstract
The mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcription. However, interleukin-4 is not required for in vivo virus spread, because mice lacking interleukin-4 or the STAT6 transcription factor showed wild-type infection of lymphoid and mammary tissue. In spite of this, mammary tumor incidence was decreased in STAT6 null mice.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Interleukin-4 / physiology*
-
Mammary Tumor Virus, Mouse / genetics
-
Mammary Tumor Virus, Mouse / physiology*
-
Mice
-
Mice, Inbred Strains
-
Mice, Knockout
-
STAT6 Transcription Factor
-
Signal Transduction / physiology
-
Trans-Activators / genetics
-
Trans-Activators / physiology
-
Up-Regulation / physiology*
Substances
-
STAT6 Transcription Factor
-
Stat6 protein, mouse
-
Trans-Activators
-
Interleukin-4