Abstract
The recent discovery linking narcolepsy, a sleep disorder characterized by very short REM sleep latency, with a neuropeptide that regulates feeding and energy metabolism, provides a way to understand how several behaviors may be disrupted as a result of a defect in this peptide. In this chapter we review the evidence linking hypocretin and sleep, including our own studies, and propose that a defect in the lateral hypothalamus that also involves the hypocretin neurons is likely to produce a disturbance in sleep, mood, appetite, and rhythms.
MeSH terms
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Animals
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Carrier Proteins / physiology
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Depressive Disorder / physiopathology
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Depressive Disorder / psychology
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Feeding and Eating Disorders / physiopathology
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Feeding and Eating Disorders / psychology
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Humans
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Hypothalamus / physiology*
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Intracellular Signaling Peptides and Proteins*
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Narcolepsy / genetics
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Narcolepsy / physiopathology
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Narcolepsy / psychology
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Neuropeptides / physiology
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Orexins
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Preoptic Area / physiology
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Sleep / physiology*
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Sleep Apnea, Obstructive / physiopathology
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Sleep Apnea, Obstructive / psychology
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Wakefulness / physiology
Substances
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Carrier Proteins
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Intracellular Signaling Peptides and Proteins
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Neuropeptides
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Orexins