Makaluvamine P, a new cytotoxic pyrroloiminoquinone from Zyzzya cf. fuliginosa

J Nat Prod. 2001 Oct;64(10):1354-6. doi: 10.1021/np010053+.

Abstract

A new pyrroloiminoquinone alkaloid (1) belonging to the makaluvamine family has been isolated from the sponge Zyzzya cf. fuliginosa collected in the waters off the Vanuatu Islands. The compound, designated makulavamine P, was characterized on the basis of its spectral data and displayed cytoxicity in the microM range on KB cells and antioxidant activity.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Australia
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • KB Cells / drug effects
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Nasopharyngeal Neoplasms
  • Porifera / chemistry*
  • Pyrroles / chemistry
  • Pyrroles / isolation & purification*
  • Pyrroles / pharmacology
  • Quinolones / chemistry
  • Quinolones / isolation & purification*
  • Quinolones / pharmacology
  • Toxicity Tests
  • Tumor Cells, Cultured / drug effects
  • Xanthine Oxidase / antagonists & inhibitors*

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Pyrroles
  • Quinolones
  • makaluvamine P
  • Xanthine Oxidase