Objective: To observe histological changes of hepatic fibrosis patients with chronic hepatitis B after recombinant human interferon-gamma treatment.
Methods: Twenty hepatic fibrosis patients with chronic hepatitis B received rhIFN-gamma treatment at the dose of 1 MU intramuscularly daily for the first three months and every other day for the next six months. Liver biopsy was performed at the start of the therapy and the end of 9-month follow-up period respectively in all patients. All liver biopsy specimens were stained with hematoxylin-eosin and picro-sirius red. Modified Scheuer and Chevallier semi-quantitative scoring system was used to assess the results. In the meantime, serum hepatic fibrosis indices and serum biochemical examination were detected.
Results: After 9 moths of treatment, the mean fibrosis score decreased from 11.24 +/- 5.34 to 8.67 +/- 4.16 (P<0.01), whereas the mean inflammation score decreased from 12.78 +/- 5.19 to 6.57 +/- 2.95 (P<0.01).
Conclusions: rhIFN-gamma showes a beneficial effect on hepatic fibrosis patients with chronic hepatitis B.