Abstract
Hibiscus acid, an alpha-amylase inhibitor isolated from roselle tea, and its derivatives were compared in an inhibition test for starch digestion. An alpha-amylase-added Caco-2 system was established as a useful model to evaluate the effects of alpha-glucosidase inhibitors on starch digestion. Hibiscus acid showed weak inhibition in this model system, and the methyl ester derivatives showed even weaker or no acitivity.
MeSH terms
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Animals
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Caco-2 Cells
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Citrates / pharmacology*
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Citric Acid / pharmacology
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Digestion / drug effects
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Glucose / metabolism
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Glycoside Hydrolase Inhibitors
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Humans
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Inhibitory Concentration 50
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Pancreas / enzymology
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Starch / metabolism*
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Swine
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alpha-Amylases / antagonists & inhibitors
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alpha-Amylases / metabolism
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alpha-Glucosidases / metabolism
Substances
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Citrates
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Glycoside Hydrolase Inhibitors
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Citric Acid
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hydroxycitric acid
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Starch
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alpha-Amylases
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alpha-Glucosidases
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Glucose