Successful treatment with steroids of upper gastrointestinal acute graft vs. host disease after hematopoietic stem cell transplantation

Endoscopy. 2001 Nov;33(11):985-7. doi: 10.1055/s-2001-17922.

Abstract

A 39-year-old man with acute myeloid leukemia underwent completely matched related hematopoietic stem cell transplantation. On post-transplantation day 83 he was diagnosed as having upper gastrointestinal graft-versus-host disease (GVHD) by endoscopic examination and pathological examination of endoscopic biopsy specimens, and daily administration of 60 mg of water-soluble prednisolone and 50 mg of cyclosporine was started. After steroid therapy, the symptoms of upper gastrointestinal GVHD disappeared completely and endoscopic findings dramatically improved.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Cyclosporine / therapeutic use
  • Endoscopy, Gastrointestinal
  • Gastrointestinal Diseases / drug therapy*
  • Gastrointestinal Diseases / etiology*
  • Gastrointestinal Diseases / pathology
  • Graft vs Host Disease / drug therapy*
  • Graft vs Host Disease / etiology*
  • Graft vs Host Disease / pathology
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Leukemia, Myeloid / pathology
  • Leukemia, Myeloid / surgery*
  • Male
  • Prednisolone / therapeutic use*

Substances

  • Immunosuppressive Agents
  • Cyclosporine
  • Prednisolone