Failure of multiple-site intradermal postexposure rabies vaccination in patients with human immunodeficiency virus with low CD4+ T lymphocyte counts

Clin Infect Dis. 2001 Nov 15;33(10):E122-4. doi: 10.1086/324087. Epub 2001 Oct 12.

Abstract

Human immunodeficiency virus (HIV)-infected patients with low CD4(+) T lymphocyte counts had a poor neutralizing antibody response to pre- and postexposure rabies vaccination. This study of HIV-infected patients with CD4(+) T lymphocyte counts < 200/microL indicated that patients had a poor response after 4-site intradermal vaccinations (4-4-4-0-2-2, doubling the intradermal doses of cell-culture rabies vaccine).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Antibodies, Viral / blood
  • CD4 Lymphocyte Count
  • Child
  • Chlorocebus aethiops
  • HIV Infections / complications*
  • HIV Infections / immunology
  • Humans
  • Injections, Intradermal
  • Neutralization Tests
  • Rabies / prevention & control*
  • Rabies Vaccines / administration & dosage*
  • Rabies Vaccines / immunology*
  • Rabies virus / immunology*
  • Treatment Failure
  • Vero Cells

Substances

  • Antibodies, Viral
  • Rabies Vaccines